Perspiration-inhibiting composition



" chloride and zinc chloride.

.7 Patented July 13,1937 2 037 152 .PERSPIRATION-INHIB ITING COMPOSITION William C. Moore, Stamford, Conn, assignor to U. 8. Industrial Alcohol 00., New York, N. Y., a corporation of West Virginia No Drawing. Application November 25, 1935,

Serial No. 51,480

9 Claims. (01. 167 -90) This invention is concerned with a solidified, positions is to heat the mixture under a reflux predominantly alcoholic compositioncontaining condenser until solution of substantially all inan astringent salt having a perspiration-inhibitgredients is effected; and then run the mixture ing property such as that possessed by aluminum into containers, with or without stirring.

4 a The alcohol, which constitutes a large or major The object of the invention is to provide a comportion of the composition, may be ethyl alcohol,

positionwhich is of smooth, salve-like consistency, or its equivalent for topical use, propyl alcohol,

has good penetrating properties and dries quickly either normal or isopropyl, or mixtures of the on the skin, and in which the astringent salt does equivalent alcohols. Where ethyl alcohol is used 10 not suffer any serious deterioration. it may be denatured according to some govern- I have found that one or morewaxes, preferm'ent formula approved for'topical use. ably the harder -waxes such as candelilla, car- The typical astringent salt used to control pernauba and beeswax, are advantageous solidifying spiration is aluminum chloride, and this may be agents for alcoholic solutions of the astringent employed in either the hydrated or the anhydrous, salt, except that as a hot solution, containing form in compositions of this invention. Zinc only the alcohol (concentrated or diluted somechloride is also efiective.

what with water), the astringent, and thewax, The following examples illustrate how the incools' and solidifies, segregation occurs to a vention has been carried out in practice.

greater or less extent. That is to say, the wax Example 1.-22.5 gms. of aluminum chloride,

tends to form lumps or aggregates which are hydrated, (AlClafil-IaO) 12.0 arms. of candelilla harder than the main mass of the material, and wax and 16.0 gms. of stearic acid were boiled these lumps or granular portions cause the prepunder a reflux condenser with an alcoholic menaration to have a rough, sandy feeling when it is struum consisting of 108 cc. of anhydrous ethyl rubbed on the skin. alcohol, denatured according to U. S. Govern- I have now discovered that the higher fatty ment formula, and 108 cc. of isopropyl alcohol acids, such as have ten to twenty carbon atoms, (98% by volume). When solution of the solid possess to a remarkable degree a property of iningredients had been effected, 0.7 cc. of perfume hibiting granulation in the solidified alcoholicbase was added and the mixture was run off into wax-astringent preparations to which the invensmall containers. When cold it formed a solid tion relates. The same effect can be had with mass of smooth salve-like consistency, small poresters of these same fatty acids which are derived tions of which could be removed in discrete quanfrom alcohols, either monohydric or polyhydric, titles from the container, by means of the fingers, having from two'to four carbon atoms, or with and applied to the human skin, as under the natural oil or fat materials containing such arms, to control or deodorize perspiration.

esters. The materials of this general category A similarv preparation, made without the which are suitable for the purposes of the invenstearic acid, was decidedly inferior to that detion-act as modifiers to prevent or reduce grainscribed in Example 1 in that it contained many iness in the solid or semi-solid anti-perspiration granular, Sandy particles which had an abrasive compositions. Thus, I have employed lauric, feel when rubbed into the skin, and, moreover,

40 myristic, palmitic, stearic and oleic acids, ethyl was much more susceptible to mechanical shock.

stearate, butyl stearate, glycol stearate, glycol When examined under a microscope with a magoleate, mutton tallow and coconut oil to accomnification of about 100 diameters, the composiplish the desired result. tion containing stearic acid was found to be sub- Another beneficial effect of such modifiers is stantially free from the waxy a regates which that they substantially eliminate the harsh a similar inspection showed to be abundantin 55 The general method of making the new comunder a reflux condenser, and the preparation sensation which might result from a residual the mixture from which the acid was omitted.

wax film on the skin. These modifiers are not Example 2.-12.4 gins. of anhydrous aluminum in themselves capable of solidifying the alcoholic chloride was added in small quantities at a time solutions of astringent salts which I employ, but to a cold mixture consisting of 12.0 gins. of canrather strangely, despite the fact that they are, delilla wax, 16 gms. of stearic acid, 108 cc. of in general, more soluble in these solutions than anhydrousethyl alcohol, denatured according to are the waxes used as solidifiers, the modifiers U. S. Government formula, and 117 cc. .of isohave the desirable eflect of increasing the. rigidpropyl alcohol (91% by volume concentration of ity of the solidified compositions. isopropanol). This mixture was then heated completed as in Example 1. The final composition was substantially the same as that of Example l in appearance, chemical constituents and general properties.

Example 3.22.5 gms. of anhydrous zinc chloride, 12.0 gms. of candelilla wax, 16 gms. stearic acid, 108 cc. of absolute ethyl alcohol and 108 cc. of (98% by volume) isopropyl alcohol were boiled under a reflux condenser until solution was effected. 0.7 cc. of perfume base was then added, and the composition poured into containers. When cold it formed. a firm, solid mass of highly astringent properties, suitable for controlling perspiration.

Example 4.-Like Example 1, except that 16.0 gms. of lauric acid was used instead of the same amount of stearic acid.

Example 5.Like Example 1, except that 16.0

gms. of myristic acid was used instead of the same amount of stearic acid.

Example 6.-Like Example 1, except that 16.0 gms. of palmitic acid was used instead of the same amount of stearicacid.

Example 7.Like Example. 1, except that 16.0 gms. of oleic acid was used instead of the same amount of stearic acid.

Example 8.Li ke Example 1, except that 16.0 gms. of ethyl stearate was used instead of the same amount of stearic acid.

Example 9.-Like Example 1, except that 16.0 gms. of glycol stearate was used instead of the same amount of stearic acid.

Example 10.Lik'e Example 1, except that 16.0 gms. of glycol oleate was used instead of the same amount of stearic acid.

Example 11 .Like Example 1, except that 16.0 gms. of coconut oil was used instead of the same amount of stearic acid.

Example 12.Like Example 1, except that 16.0 gms. of mutton tallow was used instead of the same amount of stearic acid, and 12.0 gms. of carnauba wax instead of 12.0 gms. candelilla wax.

Example 13.-Like Example 12, except that 16.0 gms. of coconut oil was used instead of the same amount of mutton tallow.

Example 14.Like Example 1, except that 16.0 gms. of butyl stearate was used instead of the same amount of stearic'acid.

.All of these examples in general possess properties similar to those of Example 1. Example 12,

however, was somewhat inferior to the others in that it was slightly grainy.

Example 15.-Like Example 1, except that 216 cc. of absolute ethyl alcohol was used instead of a mixture of ethyl and isopropyl alcohols. The resultant solid was hard and firm but was slightly more granular than Example 1.

Example '16.22.5 gms. aluminum' chloride (A1Cl3.6H2O), 12.0 gms. candelilla wax and 16.0 gms. stearic acid were boiled for more than an hour under a reflux condenser with 216 cc. of normal propyl alcohol (substantially 98% by weight). The aluminum chloride did not all dissolve, so 10 cc. water was added. In a few minutes all was in solution. 0.'l cc. of perfume base was added, after which the mixture was run into containers to cool. When it had become solid this product was found to be firm, hard, nearly white and non-granular.

Example 17.Previous experiments showed that aluminum chloride has a lower solubility in isopropyl alcohol than in ethyl alcohol. Example 17 was therefore made up like Example 1, except that the solvent used was 206 cc. of 98% isopropyl alcohol and 10 cc. water. The resultant solid alcoholic preparation was of very fine quality, being non-granular, flrm and hard. It the stearic acid is omitted, the product contains many granules.

Instead of candelilla wax, other waxes may be used. I have obtained particularly good results by substituting an equal weight of carnauba wax, or of beeswax, for the 12 gms. of candelilla used in Examples 1 and 2. If carnauba wax is used, the product has a flow point somewhat higher (65 C. vs. 58-59 C.) than has the candelilla material.

The use of carnauba and of beeswax results in compositions having somewhat lower mechanical rigidity than is obtained with candelilla wax. These waxes are, therefore, suitable for use when it is wished to dispense compositions -made according to this invention in a pasty form, or when it is desired to use collapsible tubes as containers.

Spermaceti and Chinese insect wax have also been used instead of candelilla in compositions of the type of Examples 1 and 2. In both cases the products consisted of a semi-solid felted mass of crystalline material. By increasing the solid content a better composition may be obtained,

but these individual crystalline waxes in general delilla wax instead of the other waxes mentioned gives a product light in color, with a reasonably high flow point and a resistance to mechanical shock far above that provided by carnauba or beeswax. The use of stearic acid eliminates the undesirable graininess, or segregation which occurs when no modifle'r is used, and contributes a.

desirable unctuousness or smoothness to the finished product which is lacking when the modifier is omitted. These two desirable effects are attained, to a higher degree at a reasonable cost with stearic acid than with any of the other modifiers. Glycol stearate, and myristic acid produce the same effects to almost the same degree but at a much greater cost.

Coconut oil with candelilla wax (Example 11) isalso an excellent modifier, though compositions made according to Example 11 are slightly more grainy than those made according to Examples 1 and 2. However, if carnauba wax is used, the best all round preparation containing nut oil is the modifying agent.

The novel feature of this invention is the use' of simple fatty acids, and their relatively simple esters, to eliminate graininess, reduce the harshness of the residual wax film left onthe skin, and increase mechanical rigidity of solid alcoholic compositions containing wax as a solidifier and anastringent salt to control, inhibit and deodorize perspiration.

It is, of course, understood that tinting or pigmenting materials may be added to compositions of the type disclosed herein without departing from the spirit of the invention.

I claim:

l. A solid or semi-solid composition for topical use, containing an astringent saltselected from the group consisting of aluminum chloride and zinc chloride, wax, a predominant amount of al-- cohol, and a modiflerselected'from the group consisting of the higher fatty acids andtheir esters of alcohols having two to four carbon 76 atoms, said modifier having the property of in-' 'hibiting granulation of the wax.

2.'A solid or semi-solid composition for topical use, containing an astringent salt'selected 5 from the group consisting of aluminum chloride and zinc chloride, wax, a predominant amount of alcohol, and stearic acid as a modifier to inhibit granulation of the wax.

3. A solid or semi-solid composition for topical 1 use, containing aluminum chloride, wax, a predominant amount of alcohol, and a modifier selected from the group consisting of the higher fatty acids and their esters of alcohols having two to four carbon atoms, said modifier having 15 the property of inhibiting granulation of the wax. 4. A solid or semi-solid composition for topical use, containing zinc chloride, wax, a predominant amount of alcohol, and a modifier selected from the group consisting of thehigher fatty 20 acids and their esters of alcohols having two to four carbon atoms, said modifier having the property of inhibiting granulation'ol! the wax.

- 5. A solid or semi-solid composition for topical use, containing an astringent salt selected from I 25 the group consisting of aluminum chloride'and zinc chloride, candelilla wax, a predominant amount of alcohol, and a modifier selected from the group consisting of the higher fatty acids and tht'ir ester." of alcohols havingtwo to four carbon atoms, said modifier having the property of inhibiting granulation of the wax.

-6. A solid or semi-solid composition for topical use, containing an astringent salt selected from .the group consisting of aluminum chloride and 5 zinc chloride, candelilla wax, a predominant 4 amount of alcohol, and stearic acid as a modifier to inhibit granulation of the'candelilla wax.

7. A solid or'semi-solid composition for topical use, containing aluminum chloride, wax, a predominant amount of alcohol, and stearlc acid as a modifier to inhibit granulation oi'- the wax.

8. A solid or semi-solid composition for topical use, containing aluminum chloride, candelilla wax, a predominant amount of alcohol, and stearic acid as a modifier to inhibit granulation of the candelilla wax.

9. A solid or semi-solid composition for topical use, containing an astringent salt selected from the group consisting of aluminum chloride and zinc chloride, wax, a predominant amount. of alcohol, and a natural i'atty material containing a substance from the group consisting of the higher fatty acids. and their esters of alcohols having two to four carbon atoms, said substance 2 having the property of inhibiting granulation of the wax.

, WILLIAM C. MOORE. 

